Any system can develop only if there are differences in the development of its constituent elements. Therefore, a certain level of differentiation of socio-economic systems is useful, since, by creating a certain spatial competition or tension, it contributes to overall development. However, the strengthening of regional differentiation creates problems for the implementation of effective state policy in terms of leveling the socio-economic development of the country’s regions and bringing their characteristics closer to the levels of more developed territories. As a result of the flow of capital and the able-bodied population from poor regions to rich ones, the risks of regional crises and inter-regional conflicts increase, that is, differentiation in this case discourages development, and it is necessary to reduce it.